Glycine receptor
Extracellular ligand-gated chloride channel
(Alternative nomenclature: GlyR, iGlyR)
GlyR is a neurotransmitter-gated ion channel. It is a hetero-pentamer composed of 4-TM alpha (48 kDa) and beta (58 kDa) subunits. Glycine binding to the receptor leads to an increase in the chloride conductance which causes hyperpolarization (inhibition of neuronal firing). Regulates both motor and sensory functions.
Localization:
Synapses in spinal chord and brainstem
Information links:
http://www.expasy.org/cgi-bin/niceprot.pl?P23415
http://www.expasy.org/cgi-bin/niceprot.pl?P48168
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138492
Pharmacological profiling:
Antagonists: Picrotoxine (non-competitive), Strychnin (competitive)
Agonists:
(The list is not intended to be complete)
NO QPATCH DATA AVAILABLE
Pathophysiology:
Startle disease (STHE, hyperexplexia). STHE is a neurologic disorder causing muscular rigidity and an exaggerated startle response to unexpected acoustic or tactile stimuli. Inheritance can be autosomal dominant or recessive.
Recent review articles:
Lynch JW, Callister RJ. Glycine receptors: a new therapeutic target in pain pathways. Curr Opin Investig Drugs, 7:48-53, 2006.
Zeilhofer HU. The glycinergic control of spinal pain processing. Cell Mol Life Sci., 62:2027-35, 2005.
Barry PH, Lynch JW. Ligand-gated channels. Trans Nanobioscience, 4:70-80, 2005.
Jensen ML, Schousboe A, Ahring PK. Charge selectivity of the Cys-loop family of ligand-gated ion channels. J Neurochem., 92:217-25, 2005.
QPatch written material:
Application reports:
NO QPATCH APPLICATION REPORTS AVAILABLE
Posters:
NO QPATCH POSTERS AVAILABLE
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