ASIC3
Acid Sensing Ion Channel 3
(Alternative nomenclature: DRASIC)
ASIC3 is a tetrameric extracellular proton-gated cation channel that is important for nociception. Each subunit has 2 TM. Permeable to Na+ and Ca2+.
Localization:
DRG neurons, large-diameter mechanoreceptors, unmyelinated small-diameter peptidergic nociceptors, sensory nerve terminals, rapidly adapting low-threshold mechanoreceptors, free nerve endings (nociceptors?).
Information links:
http://www.expasy.org/cgi-bin/niceprot.pl?O35240
Pharmacological profiling:
Antagonists: Amiloride, gadolinium
Agonists: H+
(The list is not intended to be complete)
QPatch concentration-response analysis:
Effects of four increasing concentrations of gadolinium (1-1000 μM) on whole-cell ASIC3 currents. Cursors at 3000 and 4500 ms define the time interval in which peak current was found.
Concentration-response relationship for the effect of gadolinium on peak ASIC3 receptor currents based on the data above. Current values were corrected for the leak.
Pathophysiology: Pain
QPatch written material:
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