Kir2.x
Inward rectifier potassium channel
(Alternative nomenclature: KCNJx, KATP )
Kir2.x is an inward rectifier 2-TM 1-P type potassium channel. Functional channel is homotetrameric associated with four sulfonylurea receptors.
Localization:
Excitable cells in heart, brain, and skeletal muscle
Information links:
http://www.expasy.org/cgi-bin/sprot-search-de?kcnj+human
QPatch inward rectifying Kir2.x whole-cell currents. Voltage protocol: voltage ramp starting at -120 mV and ending at +60 mV executed in 950 ms. Between sweeps V was held at -90 mV.
Endogenous Kir2.x channels in RBL cells.
Pharmacological profiling:
Inhibitors: N/A
Activators: N/A
(The list is not intended to be complete)
Pathophysiology:
N/A
QPatch written material:
Articles:
Increased throughput in ion channel drug development and exploration by automation of electrophysiology. American Biotechnology Laboratory 24: issue 4, 20-21, 2006 (2,87 MB)
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