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Alpha 1
Alternative nomenclature: (NaChR Alpha 1, CHRNA1)
The human muscle TE671 cell line endogenously expresses the nicotinic acetylcholine alpha 1 receptor (nAChR alpha1) (Morris et al., 1991). TE671 cells have therefore been used for experiments with nAChR alpha 1 as target.
Information links:
http://en.wikipedia.org/wiki/CHRNA1
QPatch recording of nAChR alpha1 currents:
Exposure to an increased concentration of acetylcholine showed dose dependent effects. Holding potential -60 mV. Expression system: TE671 cells endogenously expressing the nAChR alpha 1 receptors.
Pharmalogical profiling:
Inhibitors: gallamine
Activators: Acetylcholine, nicotine
(the list is not intended to be complete)
QPatch written material:
TE671 - nicotinic alpha1 currents
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