Cav3.2
Voltage dependent T-type calcium channel
(Alternative nomenclature: CACNA1H, α1H)
Cav3.2 composed of 4 homologous 6-TM repeats, a highly conserved pore loop, and a distinctive voltage sensor. The voltage dependence and fast inactivation of Cav3.2 results in transient (T-type) currents.
Localization:
Kidney, liver, heart, neurons, skeletal muscle
Information links:
http://www.expasy.org/cgi-bin/niceprot.pl?O95180
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607904
QPatch recordings of Cav3.2 whole-cell currents:
QPatch whole-cell Cav3.2 currents in response to 10 ms depolarizations (-80 to +40 mV) from a
holding potential of -90 mV. Subsequently, V was held at -60 mV for 20 ms for recording of tail currents. Finally, V was returned to -90 mV. Expression system: HEK-293.
I-V relationships for depolarization-activated Cav3.2 currents and for peak tail currents based on QPatch whole-cell current traces above.
I-V relationship for peak Cav3.2 tail currents
Pharmacological profiling:
Inhibitors: Nickel, mibefradil, kurtoxin
Activators:
(The list is not intended to be complete)
Pathophysiology:
Childhood absence epilepsy
Recent review articles:
Yunker AM, EcEnery MW. Low-voltage-activated
("T-type") calcium channels in review.
J Bioenerg Biomembr. 35:533-75, 2003.
QPatch written material:
Application reports:
HEK-Cav3.2 channels
Posters:
Pharmacological Characterization of Voltage- and Ligand-gated Ion Channels by QPatch, Japanese Pharmacological Meeting 2006 (424 kB)
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