Cav2.2
Voltage dependent N-type calcium channel
(Alternative nomenclature: CACNA1B, α1B)
Cav2.2 composed of 4 homologous 6-TM repeats, a highly conserved pore loop, and a distinctive voltage sensor.
Localization:
Neurons (presynaptic)
Information links:
http://neuromuscular.wustl.edu/mother/chan.html
QPatch recordings of Cav2.2 whole-cell currents:
QPatch whole-cell Cav2.2 currents in response to 50 ms depolarizations at 0 mV executed 5 times with an interval of 50 ms. The holding potential was -110 mV. The current sweeps are shown in the absence (saline) and presence of increasing concentrations of compound A.
Peak current from first depolarising pulse plotted as a function of the compound concentration. Data is fitted to a Hill fit.
Pharmacological profiling:
Inhibitors: ώ-conotoxin GVIA, SNX-325 Segestria spider toxin
Activators:
(The list is not intended to be complete)
Pathophysiology:
Recent review articles:
Lacinova L. Voltage dependent calcium channels.
Gen Physiol Biophys. 2005 Jun;24 Suppl 1:1-78
QPatch written material:
Application report:
HEK Cav2.2
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