CFTR
Voltage dependent: no
(Alternative nomenclature: CFTR)
Localization and function:
The cystic fibrosis transmembrane conductance regulator (CFTR) functions a a chloride channel and controls the regulation of other transport pathways. CFTR is found in the epithelial cells of many organs including the lung, liver pancreas, digestive tract, reproductive tract and skin.
Information links:
http://en.wikipedia.org/wiki/Cystic_fibrosis_
transmembrane_conductance_regulator
QPatch recording on CFTR currents:
Activation of CFTR whole-cell currents by depolarization from -100 to +100 mV from a holding potential of -60 mV. Expression system: The CFTR gene was stably transfected into the mouse embryonic fibroblast NIH/3T3 cell line.
Pharmacological profiling:
Inhibitors: glybenclamide
QPatch written material:
NIH/3T3 CFTR
page top
