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Kv1.3
Voltage dependent: shaker related

(Alternative nomenclature: KCNA3, MK3, HLK3, hPCN3, RCK3, RGK5, KV3, MBK3, HuK(III), HGK5, n-channel)

Kv1.3 is a delayed rectifier voltage-gated 6-TM 1-P type homotetrameric potassium channel.

Localization:
Skeletal muscle and lymphocytes

Information links:
http://www.expasy.org/cgi-bin/niceprot.pl?P22001

QPatch recording of Kv1.3 whole-cell currents:



QPatch Kv1.3 whole-cell currents.Voltage protocol: from the holding potential, -80mV, the cell was depolarized to +20mV for 500 ms. Expression system: CHO cells

Pharmacological profiling:
Inhibitors: N/A
Activators: N/A
(The list is not intended to be complete)


QPatch test of quinidine. Four increasing concentrations (0.1-100 μM) were applied to CHO cells expressing Kv1.3. I-t plot.


Concentration-response relationship based on ion currents shown in the i-t plot above.

Pathophysiology: N/A

QPatch written material:

Application reports:
Ion channel drug screening with QPatch 16 (358 kB)

Posters:
Pharmacological Characterization of Voltage- and Ligand-gated Ion Channels by QPatch, Japanese Pharmacological Meeting 2006 (kB 424)

Articles:
Increased throughput in ion channel drug development and exploration by automation of electrophysiology. American Biotechnology Laboratory 24: issue 4, 20-21, 2006 (2,87 MB) 


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