hGRIK2 receptor (Glutamate Receptor, Ionotropic, Kainate2)
(Alternative nomenclature: iGluR6, Glutamate Receptor 6, GLR6)
hGRIK2 is a homomeric ligand-gated cation channel. The Activity of this Ionotrophic glutamate receptor is mediating fast excitatory transmission in CNS. The receptor may have a role in synaptic plasticity and could be important for learning and memory. It may also be involved in the transmission of light information from the retina to the hypothalamus.
Localization:
Cell membrane, mammalian brain.
http://www.genecards.org/cgi-bin/carddisp.pl?gene=GRIK2
QPatch recording of hERG currents:
QPatch recordings showing GRIK2 current traces elicited by 12 increasing doses of Glutamate. Holding potential: -60 mV. Expression system: HEK293
Pharmacological profiling:
Agonists: glutamate, kainate, SYM2081, domate
Antagonists: CNQX, NBQX
QPatch concentration - response analysis:
QPatch concentration-response test of glutamate. 12 increasing concentrations of glutamate was added to one cell and the resulting dose-response plot is shown. The current signal seems to be reduced at a certain maximum dose.
QPatch written material:
Application reports:
HEK293-GRIK2 Glutamate receptor
References:
Paternain AV., Cohen A., Stern-Bach Y., Lerma J. A role for extracellular Na+ in the channel gating of native and recombinant kainite receptors. The journal of neuroscience. 2003 Sept. 23(25):8641-8648
Lerma J., Paternain AV., Rodríguez-Moreno A., López-García JC. Molecular physiology of kainite receptors. Physiological reviews. 2001 July 81(3): 971-998
Everts I., Petroski R., Kizelsztein P., Teichberg VI., Heinemann SF., Hollmann M. Lectin-induced inhibition of desensitization og the kainite receptor GluR6 depends on the activation state and can be mediated by a single native or ectopic N-linked carbohydrate side chain. The journal of neuroscience. 1999 Feb. 19(3): 916-927
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