TRPM5
Transient Receptor Potential Channel M5
(Alternative nomenclature: LTRPC5, MLSN1- and TRP-related gene1; MTR1)
TRPM5 tetrameric consisting of four 5-TM α-subunits. Strong outward rectificier. Nonselective among monovalent cations. Not permeable to divalent cations. Regulated by intracellular Ca2+ (activates and desensitizes) and PIP2 (reverses desensitization). Taste transduction channel.
Localization:
Widely expressed
Information links:
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604600
QPatch recording of TRPM5 currents:
TRPM5 whole-cell currents in response to a voltage ramp revealing marked outward rectification
Pharmacological profiling:
Inhibitors: Ruthenium red, Phosphatidylinositol (4,5)-bisphosphate
Activators: Capsaicin, Resiniferatoxin, Anandamide
(The list is not intended to be complete)
Pathophysiology: Associated with Beckwith-Wiedemann syndrome
Recent review articles:
Owsianik G, Talavera K, Voets T, Nilius B. Permeation and selectivity of TRP channels.
Annu Rev Physiol. 68:685-717, 2006.
QPatch written material: N/A
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