Nav1.3
Voltage dependent sodium channel
(Alternative nomenclature: SCN3A, NAC3)
Nav1.3 is a 24TM (four 6TM repeats) type voltage-gated sodium channel. Downregulated by NGF and GDNF.
Localization:
Widespread in brain.
Information links:
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=182391
QPatch recordings of Nav1.3 currents:
Whole-cell Nav1.3 current recordings. Voltage protocol: 20 ms depolarization to 0 mV from a holding potential of –90 mV. Expression system CHO cells.
Current-voltage relationship for peak whole-cell Nav1.3 sodium currents.
Pharmacological profiling:
Inhibitors: tetrodotoxin, saxitoxin
Activators: N/A
(The list is not intended to be complete)
QPatch concentration-response analysis:
Whole-cell Nav1.3 currents in response to increasing concentrations (0.5-500 nM) of tetrodotoxin (TTX).
Concentration-response relationship for TTX based on the whole-cell Nav1.3 currents presented above. IC50 = 6.1 nM.
Pathophysiology:
Seizures
QPatch written material:
Posters:
Biophysical and pharmacological profiling of multiple NAv subtypes on QPatch (1.4 MB)
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