KCNQ4
Voltage dependent: KQT related
(Alternative nomenclature: Kv7.4)
KCNQ4 is a slow delayed rectifier voltage-gated 6-TM 1-P type potassium channel. Homotetrameric.
Localization:
Cochlea: Sensory outer, but not inner hair cells; vestibular organs, brainstem: auditory nuclei
Information links:
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603537
QPatch recording of KCNQ4 currents:
(Courtesy of Dr. Mads P.G. Korsgaard, NeuroSearch)
Activation of KCNQ4 whole-cell currents by depolarizations from -90 to +40 mV from a holding potential of -100 mV. Expression system: HEK-293.
I-V relationship based on the KCNQ4 whole-cell currents presented above.
Pharmacological profiling:
Inhibitors: Linopirdine, DMP543, XE-991
Activators: Retigabine, BMS-204352
(The list is not intended to be complete)
QPatch concentration-response analysis:
(Courtesy of Dr. Mads P.G. Korsgaard, NeuroSearch)
Effect of on the KCNQ activator retigabine (30 μM) on KCNQ4 whole-cell currents (red traces)
I-V relationschips with (red) or without retigabine based on currents shown above.
Pathophysiology:
Nonsyndromic sensorineural hearing loss, dominant (DFNA2)
Recent review articles:
Gribkoff VK. The therapeutic potential of neuronal KCNQ channel modulators. Expert Opin Ther Targets;7:737-48, 2003.
QPatch written material:
N/A
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