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Kv1.5
Voltage dependent: shaker related

(Alternative nomenclature: KCNA3, HK2, hPCN1, KV1, RK3, HCK1, fHK, RMK2, HuK(II))

Kv1.5 is a delayed rectifier voltage-gated 6-TM 1-P type potassium channel. Homotetrameric.

Localization:
Heart and pancreatic islets.

Information links:
http://www.expasy.org/cgi-bin/niceprot.pl?P22460

 
Voltage protocol: From the holding potential, -80mV, the cell was depolarized to -30mV for 100 ms. Expression system: CHO cells

Pharmacological profiling:
Inhibitors: Quinidine 
Activators: N/A
(The list is not intended to be complete)


QPatch test of quinidine. Four increasing concentrations (0.1-100 μM) were applied to CHO cells expressing Kv1.3. I-t plot. 


Concentration-response relationship based on the steady-state currents shown in the above I-t plot.

Pathophysiology: N/A

QPatch written material:

Application reports:
Ion channel drug screening with QPatch 16 (358 kB)

Posters:
Pharmacological Characterization of Voltage- and Ligand-gated Ion Channels by QPatch, 
Japanese Pharmacological Meeting 2006 (kB 424)

Articles:
Increased throughput in ion channel drug development and exploration by automation of electrophysiology. American Biotechnology Laboratory 24: issue 4, 20-21, 2006 (2,87 MB) 


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