TRPM8
Transient Receptor Potential Channel M8
(Alternative nomenclature: TRP-p8, CMR1 - cold and menthol receptor 1)
TRPM8 is a tetrameric protein with six transmembrane segments per subunit. TRPM8 is a non-selective cation channel, and is permeable to both monovalent and divalent cations. It is regulated by PIP2 and Ca2+, equivalently to other ion channels in the TRP family. It is believed to mediate cold sensation in mammals.
Localization: Prostate, primary tumours of breast, colon, lung and skin origin, sensory neurons, ganglion cells, gastric fundus, vascular smooth muscle, liver, bladder urothelium, male genital tract.
Information links:
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604600
Pharmacological profiling:
Inhibitors: 2-APB, BCTC, capsazepine
Activators: Menthol, icilin, eucalyptol, linalool, geraniol.
(The list is not complete)
QPatch recordings of TRPM8 currents:
IV-characterization of TRPM8 whole-cell current. Menthol is used as reference compound.
TRPM8 whole-cell currents in response to a voltage ramp. Concentration-response experiment with increasing icilin concentration.
IT-plot of concentration-response experiment with icilin.
Hill fit of concentration-response experiment with icilin.
Recent Review articles:
Voets T, Owsianik G, Nilius B; TRPM8, Handb Exp Pharmacol. 2007;(179):329-44
QPatch written material:
The cold receptor TRPM8 on QPatch
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